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Nolvadex vs. Clomid

Clomiphene vs. Tamoxifen

Clomid (Clomiphene) and Nolvadex (Tamoxifen) are drugs that are both classied as Antiestrogens. Although their mechanism of action is very similar they are still different drugs and each has its drawbacks and advantages.

Nolvadex is FDA approved for the treatment of breast cancer in women and men. The most common off label use of Nolvadex is to stop or cure Gynecomastia ('man boobs') in men. It is known that athletes who use steroids use Nolvadex in order to prevent Gynecomasia symptomps. Nolvadex works by competeing for the estrogen receptors which exist primarily in the nipple area. When the Nolvadex attaches to the receptors it does not let estrogen attach to the receptors, hence it prevents fat tissues or fibrous tissues from forming in the nipple area.

Clomid if FDA approved to treat infertility in women. In men, a common off label use of Clomid is to treat male infertility such as low-sperm count and to stimulate natural testosterone production. Men who use performance enhancing drugs like steroids, use Clomid after they discontinue the steroids use referred to as cycle. Steroids cause a partial or complete shutdown of natural testosterone production as well as fertility issues. Clomid helps the body to increase the natural production of testosterone, increase the testes size which are shrunk during steroids abuse.

Since both Nolvadex and Clomid work the same pathways as antiestrogens, it is now known that some athletes use Nolvadex for PCT (Post Cycle Therapy) for stimulating natural teststerone production just like Clomid does. There is no definite evidence to support that Clomid is more effective than Nolvadex or viceversa.

Men who experience side effects from Clomid may switch to Nolvadex. The common Clomid side effects are visual problems, though some report acne and 'mental sensitivity'.

Some combine an antiestrogen like Clomid or Nolvadex along with anti-aromatase like Arimidex (Anastrozole), Letrozole (Femara) or Aromasin (Exemestane).

Advantages of Nolvadex
  • Believed to be more potent than Clomid as an anti-estrogen and stronger to combat stop and Gynecomastia.
  • The most common anti-estrogen so has a proven success record among users.
  • Does not cause visual problems.
Advantages of Clomid
  • Believed to work better than Nolvadex for increasing testosterone production.
  • Have been used by many doctors as an off label use in Men to treat fertility and lack of testosterone.
  • Some medications such as anti-depressants interfere with Nolvadex, making it ineffective, in such cases Clomid may be the only effective alternative.



ALWAYS CONSULT WITH YOUR DOCTOR AS TO WHICH TREATMENT IS SUITED FOR YOUR CONDITION, DO NOT SWITCH FROM ONE DRUG TO ANOTHER WITHOUT DOCTOR APPROVAL.

THE INFORMATION PRESENTED HERE IS FOR ENTERTAINMENT PURPOSES ONLY. IT WAS NOT WRITTEN BY MEDICAL PROFESSIONALS. THIS INFORMATION MAY NOT SERVE AS ANY KIND OF BASIS FOR MEDICAL EVALUATION OR ANY OTHER MEDICAL ISSUE WHATSOEVER. ONLY USE NOLVADEX AS INSTRUCTED BY A LICENSED DOCTOR.

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